Dis identifys DEFINITION Osteogenisis imperfecta (OI) is ?a r atomic number 18 genetic disorder of collagen tax write-off associated with broad spectrum of musculoskeletal problems, intimately notably bowing and fractures of the extremities, go across weakness, ligamentous laxity, and spinal deformities.? (Binder, 386). Other collagen-containing extraskeletal tissues, such as the sclerae, the teeth, and the heart valves are alike affected to a variable degree. OI has a ? everyday attribute of bony fragility associated with regretful formation of collagen by osteoblasts and fibroblasts.
? (Smi th, 1983, 13) This disease, involving defective development of the connective tissues, is usually the pass on of the autosomal dominant gene, but can also be the sequel of the autosomal recessive gene. Spontaneous mutations are common and the clinical presentation of the disease remains to be quite broad. (Binder, 386) OI is most commonly referred to as ?brittle bones?, but new(prenominal) name calling include: fragilitas ossium, hypola...If you want to get a ample essay, order it on our website:
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